GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tyr | affects binding | ISO | Tyr (Mus musculus) | 6480464 | CTD | TYR protein binds to Copper | PMID:11781109 | Tyr | multiple interactions | ISO | Tyr (Mus musculus) | 6480464 | CTD | [SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of TYR protein; Copper inhibits the reaction [[SLC31A1 gene mutant form affects the abundance of Copper] which results in decreased activity of TYR protein] | PMID:12177073 | Tyr | multiple interactions | ISO | TYR (Homo sapiens) | 6480464 | CTD | [CLDN3 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]; [CLDN4 protein results in increased abundance of Copper] promotes the reaction [[TYR protein results in increased oxidation of Levodopa] which results in increased chemical synthesis of Melanins]; [Zinc analog co-treated with Copper analog] inhibits the reaction [Colforsin results in increased expression of TYR mRNA] | PMID:23053666 PMID:23700242 | | ||||||||||||||||||||||
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