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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1589591 Species: Rattus norvegicus RGD Object: Gene Symbol: Eif2a Name: eukaryotic translation initiation factor 2A

Acc ID: CHEBI:9516 Term: thapsigargin Definition: A hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca(2+)-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations. CasRN: 67526-95-8 Chemical ID: MESH:D019284

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1605026	6480464	CTD	Doxorubicin promotes the reaction [Thapsigargin results in increased phosphorylation of EIF2A protein]	PMID:16298333
increases phosphorylation	ISO	RGD:1605026	6480464	CTD	Thapsigargin results in increased phosphorylation of EIF2A protein	PMID:17353921 PMID:16298333 PMID:19428936
multiple interactions	ISO	RGD:1619851	6480464	CTD	Thapsigargin promotes the reaction [EIF2AK3 protein results in increased phosphorylation of EIF2A protein]	PMID:17283163
increases phosphorylation	ISO	RGD:1619851	6480464	CTD	Thapsigargin results in increased phosphorylation of EIF2A protein	PMID:12606582 PMID:17283163 PMID:20589738
increases phosphorylation	EXP		6480464	CTD	Thapsigargin results in increased phosphorylation of EIF2A protein	PMID:19285962
increases phosphorylation	ISO	RGD:1605026	6480464	CTD	Thapsigargin results in increased phosphorylation of EIF2A protein	PMID:16298333 PMID:19428936 PMID:17353921
increases phosphorylation	ISO	RGD:1619851	6480464	CTD	Thapsigargin results in increased phosphorylation of EIF2A protein	PMID:17283163 PMID:12606582 PMID:20589738
increases phosphorylation	ISO	RGD:1605026	6480464	CTD	Thapsigargin results in increased phosphorylation of EIF2A protein	PMID:19428936 PMID:17353921 PMID:16298333
increases phosphorylation	ISO	RGD:1619851	6480464	CTD	Thapsigargin results in increased phosphorylation of EIF2A protein	PMID:12606582 PMID:20589738 PMID:17283163
increases phosphorylation	ISO	RGD:1619851	6480464	CTD	Thapsigargin results in increased phosphorylation of EIF2A protein	PMID:17283163 PMID:20589738 PMID:12606582
increases phosphorylation	ISO	RGD:1619851	6480464	CTD	Thapsigargin results in increased phosphorylation of EIF2A protein	PMID:20589738 PMID:12606582 PMID:17283163
increases phosphorylation	ISO	RGD:1605026	6480464	CTD	Thapsigargin results in increased phosphorylation of EIF2A protein	PMID:16298333 PMID:17353921 PMID:19428936