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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1586200 Species: Rattus norvegicus RGD Object: Gene Symbol: Apex2l1 Name: APEX nuclease (apurinic/apyrimidinic endonuclease) 2-like 1

Acc ID: CHEBI:32509 Term: pirinixic acid Definition: An aryl sulfide that has formula C14H14ClN3O2S. CasRN: 50892-23-4 Chemical ID: MESH:C006253

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1558522	6480464	CTD	NCF1 protein affects the reaction [pirinixic acid results in decreased expression of APEX2 mRNA] PPARA protein promotes the reaction [pirinixic acid results in decreased expression of APEX2 mRNA]	PMID:17950772
decreases expression	ISO	RGD:1558522	6480464	CTD	pirinixic acid results in decreased expression of APEX2 mRNA	PMID:17950772