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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1586165
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kmt2a
Name: lysine methyltransferase 2A
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kmt2adecreases response to substanceISOKMT2A (Homo sapiens)6480464CTDKMT2A gene mutant form results in decreased susceptibility to Doxorubicin; KMT2A mRNA results in decreased susceptibility to DoxorubicinPMID:14712291 PMID:16322897
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