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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583621
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tcf7l2
Name: transcription factor 7 like 2
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tcf7l2affects expressionISOTCF7L2 (Homo sapiens)6480464CTDValproic Acid affects the expression of TCF7L2 mRNAPMID:25979313
Tcf7l2decreases expressionISOTCF7L2 (Homo sapiens)6480464CTDValproic Acid results in decreased expression of TCF7L2 mRNAPMID:23179753 PMID:24935251 PMID:27188386 PMID:28001369
Tcf7l2decreases methylationISOTCF7L2 (Homo sapiens)6480464CTDValproic Acid results in decreased methylation of TCF7L2 genePMID:28853863 PMID:29201983
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