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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583621
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tcf7l2
Name: transcription factor 7 like 2
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tcf7l2multiple interactionsISOTCF7L2 (Homo sapiens)6480464CTDCurcumin inhibits the reaction [CTNNB1 protein binds to TCF7L2 protein]; Curcumin results in decreased activity of [CTNNB1 protein binds to TCF7L2 protein]PMID:19294764
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