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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583621
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tcf7l2
Name: transcription factor 7 like 2
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tcf7l2increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of TCF7L2 mRNAPMID:34747641
Tcf7l2affects expressionISOTcf7l2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of TCF7L2 mRNAPMID:21570461 PMID:24058054 PMID:24680724
Tcf7l2decreases expressionISOTcf7l2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of TCF7L2 mRNAPMID:19465110
Tcf7l2increases expressionISOTCF7L2 (Homo sapiens)6480464CTDTetrachlorodibenzodioxin results in increased expression of TCF7L2 mRNAPMID:19901195
Tcf7l2increases expressionISOTcf7l2 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of TCF7L2 mRNAPMID:19770486
Tcf7l2multiple interactionsISOTcf7l2 (Mus musculus)6480464CTD[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of TCF7L2 mRNAPMID:25975270
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