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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1583230
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rarg
Name: retinoic acid receptor, gamma
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rargaffects bindingISORARG (Homo sapiens)6480464CTDTretinoin binds to RARG proteinPMID:1318502 PMID:31195007
Rargaffects localizationISORarg (Mus musculus)6480464CTDTretinoin affects the localization of RARG proteinPMID:16417947
Rargaffects response to substanceISORARG (Homo sapiens)6480464CTDRARG protein affects the susceptibility to TretinoinPMID:11340568
Rargdecreases expressionISORarg (Mus musculus)6480464CTDTretinoin results in decreased expression of RARG mRNAPMID:16604517
Rargdecreases expressionISORARG (Homo sapiens)6480464CTDTretinoin results in decreased expression of RARG proteinPMID:15375546 PMID:19812349
Rargdecreases response to substanceISORarg (Mus musculus)6480464CTDRARG gene mutant form results in decreased susceptibility to TretinoinPMID:10748128
Rargincreases activityISORarg (Mus musculus)6480464CTDTretinoin results in increased activity of RARG proteinPMID:12223961
Rargincreases activityISORARG (Homo sapiens)6480464CTDTretinoin results in increased activity of RARG proteinPMID:25492813 PMID:30639747
Rargincreases expressionISORarg (Mus musculus)6480464CTDTretinoin results in increased expression of RARG; Tretinoin results in increased expression of RARG mRNAPMID:11237167 PMID:16291826 PMID:7934625
Rargincreases expressionISORARG (Homo sapiens)6480464CTDTretinoin results in increased expression of RARG mRNAPMID:10866818 PMID:16007204 PMID:17134824 PMID:20507312 PMID:21393419 PMID:22906706 PMID:25725299 PMID:33167477 PMID:36805303
Rargincreases phosphorylationISORarg (Mus musculus)6480464CTDTretinoin results in increased phosphorylation of RARG proteinPMID:12032135
Rargincreases response to substanceISORARG (Homo sapiens)6480464CTDRARG protein results in increased susceptibility to TretinoinPMID:16236281
Rargmultiple interactionsISORarg (Mus musculus)6480464CTDTretinoin binds to and results in increased activity of RARG protein; Tretinoin inhibits the reaction [RARG gene mutant form results in increased expression of ITGB1 mRNA]; Tretinoin promotes the reaction [[RARG protein binds to RXRA protein] which binds to CYP26A1 promoter]PMID:10748128 PMID:12504905 PMID:16053444 PMID:16839186
Rargmultiple interactionsISORARG (Homo sapiens)6480464CTD[Decitabine co-treated with Tretinoin] results in increased expression of RARG mRNA; CD2665 inhibits the reaction [Tretinoin results in increased expression of RARG mRNA]; IFNG protein promotes the reaction [Tretinoin results in increased expression of RARG mRNA]; RARG protein promotes the reaction [Tretinoin results in increased expression of VEGFA mRNA]; Tretinoin binds to and results in increased activity of RARG protein; Tretinoin inhibits the reaction [RARG protein binds to FOLR2 promoter]; Tretinoin promotes the reaction [MAPT protein affects the localization of [MAPT protein binds to RARG protein]]; Tretinoin promotes the reaction [RARG protein binds to CD1D promoter]; Tretinoin results in increased activity of [RARG protein binds to RXRA protein]; Tretinoin results in increased expression of and results in increased activity of RARG protein; trichostatin A promotes the reaction [Tretinoin inhibits the reaction [RARG protein binds to FOLR2 promoter]]; triphenyl phosphate inhibits the reaction [Tretinoin results in increased expression of RARG mRNA]PMID:15615532 PMID:16007204 PMID:16158052 PMID:16417947 PMID:16740727 PMID:16788091 PMID:17170094 PMID:17392484 PMID:19524134 PMID:25725299 PMID:30639747
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