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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:61080
Term: romidepsin
Definition: A cyclodepsipeptide consisting of the cyclic disulfide of (2Z)-2-aminobut-2-enoyl, L-valyl, (3S,4E)-3-hydroxy-7-sulfanylhept-4-enoyl, D-valyl and D-cysteinyl residues coupled in sequence and cyclised head-to tail.
Chemical ID: MESH:C087123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axincreases phosphorylationISOH2AX (Homo sapiens)6480464CTDromidepsin results in increased phosphorylation of H2AX proteinPMID:34665271
H2axmultiple interactionsISOH2AX (Homo sapiens)6480464CTD[Bortezomib co-treated with romidepsin] results in increased phosphorylation of H2AX protein; Acetylcysteine inhibits the reaction [[Bortezomib co-treated with romidepsin] results in increased phosphorylation of H2AX protein]; quizartinib promotes the reaction [romidepsin results in increased phosphorylation of H2AX protein]; romidepsin promotes the reaction [quizartinib results in increased phosphorylation of H2AX protein]PMID:15173094 PMID:34665271
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