GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | H2ax | increases expression | EXP | | 6480464 | CTD | Arsenic Trioxide results in increased expression of H2AX protein | PMID:23337567 | H2ax | multiple interactions | EXP | | 6480464 | CTD | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Arsenic Trioxide results in increased expression of H2AX protein] | PMID:23337567 | H2ax | increases expression | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased expression of H2AX protein; Arsenic Trioxide results in increased expression of H2AX protein modified form | PMID:28265077 PMID:28318385 PMID:31597699 | H2ax | increases expression | ISO | H2ax (Mus musculus) | 6480464 | CTD | Arsenic Trioxide results in increased expression of H2AX protein modified form | PMID:28265077 | H2ax | increases phosphorylation | ISO | H2AX (Homo sapiens) | 6480464 | CTD | Arsenic Trioxide results in increased phosphorylation of H2AX protein | PMID:16891316 PMID:23861973 | H2ax | multiple interactions | ISO | H2AX (Homo sapiens) | 6480464 | CTD | [Arsenic Trioxide co-treated with ruxolitinib] results in increased phosphorylation of H2AX protein; [Arsenic Trioxide co-treated with Sulindac] results in increased phosphorylation of H2AX protein; Arsenic Trioxide inhibits the reaction [SHH protein inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein]]; MUS81 protein mutant form inhibits the reaction [Arsenic Trioxide results in increased expression of H2AX protein modified form] | PMID:18636201 PMID:23861973 PMID:28318385 PMID:30012499 | | ||||||||||||||||||||||
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