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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axdecreases response to substanceISOH2ax (Mus musculus)6480464CTDH2AX protein results in decreased susceptibility to RotenonePMID:21555580
H2axincreases phosphorylationISOH2ax (Mus musculus)6480464CTDRotenone results in increased phosphorylation of H2AX proteinPMID:23619996
H2axmultiple interactionsISOH2AX (Homo sapiens)6480464CTD[PSME4 protein affects the susceptibility to Rotenone] which results in decreased expression of H2AX protein modified formPMID:32368861
H2axmultiple interactionsISOH2ax (Mus musculus)6480464CTDCASP1 gene mutant form inhibits the reaction [Rotenone results in increased phosphorylation of H2AX protein]; NLRP3 gene mutant form inhibits the reaction [Rotenone results in increased phosphorylation of H2AX protein]PMID:23619996
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