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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:27086
Term: tributylstannane
Definition: An organotin compound that has formula C12H28Sn.
Chemical ID: MESH:C011559
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axincreases expressionEXP 6480464CTDtributyltin results in increased expression of H2AX protein modified formPMID:26079211
H2axmultiple interactionsEXP 6480464CTDAcetylcysteine inhibits the reaction [tributyltin results in increased expression of H2AX protein modified form]; Phycocyanin inhibits the reaction [tributyltin results in increased expression of H2AX protein modified form]PMID:26079211
H2axincreases expressionISOH2AX (Homo sapiens)6480464CTDtributyltin results in increased expression of H2AX protein modified formPMID:31401084
H2axincreases phosphorylationISOH2AX (Homo sapiens)6480464CTDtributyltin results in increased phosphorylation of H2AX proteinPMID:36319700
H2axincreases phosphorylationISOH2ax (Mus musculus)6480464CTDtributyltin results in increased phosphorylation of H2AX proteinPMID:36319700
H2axmultiple interactionsISOH2AX (Homo sapiens)6480464CTD2-(2,6-dimethylmorpholin-4-yl)-N-(5-(6-morpholin-4-yl-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide inhibits the reaction [tributyltin results in increased phosphorylation of H2AX protein]; DFFB protein promotes the reaction [tributyltin results in increased expression of H2AX protein modified form]PMID:31401084 PMID:36319700
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