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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566119
Species: Rattus norvegicus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:17775
Term: 7,9-dihydro-1H-purine-2,6,8(3H)-trione
Definition: An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8.
Chemical ID: MESH:D014527
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axincreases phosphorylationISOH2ax (Mus musculus)6480464CTDUric Acid results in increased phosphorylation of H2AX proteinPMID:23619996
H2axmultiple interactionsISOH2ax (Mus musculus)6480464CTDCASP1 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]; NLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AX protein]PMID:23619996
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