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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1564531
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Trpv3
Name: transient receptor potential cation channel, subfamily V, member 3
Acc ID: CHEBI:3440
Term: carvacrol
Definition: A phenol that is a natural monoterpene derivative of cymene. An inhibitor of bacterial growth, it is used as a food additive. Potent activator of the human ion channels transient receptor potential V3 (TRPV3) and A1 (TRPA1).
Chemical ID: MESH:C073316
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trpv3multiple interactionsEXP 6480464CTD[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium; [carvacrol results in increased activity of TRPV3 protein] which results in increased transport of Calcium; carvacrol binds to and results in increased activity of TRPV3 protein; Ruthenium Red inhibits the reaction [[carvacrol binds to and results in increased activity of TRPV3 protein] which results in increased transport of Calcium]PMID:16617338 PMID:20086034
Trpv3affects response to substanceISOTrpv3 (Mus musculus)6480464CTDTRPV3 protein affects the susceptibility to carvacrolPMID:32535744
Trpv3increases activityISOTRPV3 (Homo sapiens)6480464CTDcarvacrol results in increased activity of TRPV3 proteinPMID:16617338 PMID:29658714
Trpv3increases activityISOTrpv3 (Mus musculus)6480464CTDcarvacrol results in increased activity of TRPV3 proteinPMID:16617338
Trpv3increases response to substanceISOTRPV3 (Homo sapiens)6480464CTDTRPV3 protein results in increased susceptibility to carvacrolPMID:29658714
Trpv3multiple interactionsISOTRPV3 (Homo sapiens)6480464CTDTRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of EGFR protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of PIK3CA protein]; TRPV3 protein affects the reaction [carvacrol results in increased phosphorylation of RELA protein]PMID:32535744
Trpv3multiple interactionsISOTrpv3 (Mus musculus)6480464CTD[carvacrol results in increased activity of TRPV3 protein] which results in increased transport of CalciumPMID:16617338
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