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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1562975
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kdm1a
Name: lysine demethylase 1A
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kdm1adecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of KDM1A mRNAPMID:33387578
Kdm1aaffects expressionISOKdm1a (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of KDM1A mRNAPMID:21570461 PMID:24058054
Kdm1amultiple interactionsISOKdm1a (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of KDM1A mRNA; Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to KDM1A promoter]PMID:17942748 PMID:19654925
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