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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553569 Species: Mus musculus RGD Object: Gene Symbol: Nr3c2 Name: nuclear receptor subfamily 3, group C, member 2

Acc ID: CHEBI:27584 Term: aldosterone Definition: A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. CasRN: 52-39-1 Chemical ID: MESH:D000450

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:733363	6480464	CTD	Aldosterone binds to and results in increased activity of NR3C2 protein Dihydrotestosterone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] Metribolone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein] Testosterone inhibits the reaction [Aldosterone results in increased activity of NR3C2 protein]	PMID:17105867
affects localization	ISO	RGD:733363	6480464	CTD	Aldosterone affects the localization of NR3C2 protein	PMID:17596522
increases activity	ISO	RGD:733363	6480464	CTD	Aldosterone results in increased activity of NR3C2 protein	PMID:15780662
multiple interactions	ISO	RGD:3094	6480464	CTD	Aldosterone promotes the reaction [NR3C2 protein binds to CREBBP protein] Aldosterone results in increased expression of and results in increased localization of NR3C2 protein	PMID:19966502
decreases expression	ISO	RGD:3094	6480464	CTD	Aldosterone results in decreased expression of NR3C2 mRNA	PMID:8969928
increases activity	ISO	RGD:3094	6480464	CTD	Aldosterone results in increased activity of NR3C2 protein	PMID:15974890
multiple interactions	ISO	RGD:3094	6480464	CTD	NR3C2 protein promotes the reaction [Aldosterone results in increased expression of GAS6 protein]	PMID:19564549
multiple interactions	ISO	RGD:3094	6480464	CTD	torsemide inhibits the reaction [Aldosterone binds to NR3C2 protein]	PMID:7954537
increases expression	ISO	RGD:733363	6480464	CTD	Aldosterone results in increased expression of NR3C2 protein Aldosterone results in increased expression of NR3C2 mRNA	PMID:20508287