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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1553531 Species: Mus musculus RGD Object: Gene Symbol: Rac1 Name: RAS-related C3 botulinum substrate 1

Acc ID: CHEBI:40303 Term: lovastatin Definition: A fatty acid ester that has formula C24H36O5. CasRN: 75330-75-5 Chemical ID: MESH:D008148

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1605432	6480464	CTD	geranylgeraniol inhibits the reaction [Lovastatin affects the localization of RAC1 protein] Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RAC1 protein]	PMID:12933658
affects localization	ISO	RGD:1605432	6480464	CTD	Lovastatin affects the localization of RAC1 protein	PMID:21356574 PMID:12933658
increases expression	ISO	RGD:1605432	6480464	CTD	Lovastatin results in increased expression of RAC1 protein	PMID:18766339
decreases activity	ISO	RGD:1605432	6480464	CTD	Lovastatin results in decreased activity of RAC1 protein	PMID:19360310
affects localization	ISO	RGD:1605432	6480464	CTD	Lovastatin affects the localization of RAC1 protein	PMID:12933658 PMID:21356574