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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552464 Species: Mus musculus RGD Object: Gene Symbol: Tek Name: endothelial-specific receptor tyrosine kinase

Acc ID: CHEBI:7476 Term: naproxen Definition: A non-steroidal anti-inflammatory drug commonly used for the reduction of pain, fever, inflammation and stiffness caused by conditions such as osteoarthritis, kidney stones, rheumatoid arthritis, psoriatic arthritis, gout, ankylosing spondylitis, menstrual cramps, tendinitis, bursitis, and for the treatment of primary dysmenorrhea. It works by inhibiting both the COX-1 and COX-2 enzymes. CasRN: 22204-53-1 Chemical ID: MESH:D009288

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:620980	6480464	CTD	[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of TEK protein] Naproxen inhibits the reaction [Capsaicin results in increased expression of TEK protein]	PMID:22150557