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GENE - TERM ANNOTATION REPORT

RGD ID: 1552054 Species: Mus musculus RGD Object: Gene Symbol: Adipoq Name: adiponectin, C1Q and collagen domain containing

Acc ID: RDO:0005703 Term: Graves Disease Definition: A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
	ISS	RGD:1351472	5686857	RGD	associated with thyroid diseases protein:increased expression:serum
Severity	ISS	RGD:1351472	5686818	RGD	protein:increased expression:serum