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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550861 Species: Mus musculus RGD Object: Gene Symbol: Plg Name: plasminogen

Acc ID: CHEBI:3750 Term: clofibrate Definition: A propanoate ester that has formula C12H15ClO3. CasRN: 637-07-0 Chemical ID: MESH:D002994

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects expression	ISO	RGD:619893	6480464	CTD	Clofibrate affects the expression of PLG mRNA	PMID:19483382
affects expression	ISO	RGD:1343043	6480464	CTD	Clofibrate affects the expression of PLG protein	PMID:131008
decreases expression	EXP		6480464	CTD	Clofibrate results in decreased expression of PLG mRNA	PMID:17585979
multiple interactions	EXP		6480464	CTD	[Clofibrate co-treated with Acetaminophen] affects the expression of PLG mRNA PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PLG mRNA]	PMID:17585979
decreases expression	ISO	RGD:619893	6480464	CTD	Clofibrate results in decreased expression of PLG mRNA	PMID:12851107