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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359491
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pou5f1
Name: POU class 5 homeobox 1
Acc ID: CHEBI:3962
Term: curcumin
Definition: A beta-diketone that is methane in which two of the hydrogens are substituted by feruloyl groups. A natural dyestuff found in the root of Curcuma longa.
Chemical ID: MESH:D003474
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pou5f1decreases expressionISOPOU5F1 (Homo sapiens)6480464CTDCurcumin results in decreased expression of POU5F1 mRNA; Curcumin results in decreased expression of POU5F1 proteinPMID:33539684
Pou5f1increases expressionISOPou5f1 (Mus musculus)6480464CTDCurcumin results in increased expression of POU5F1 mRNA; Curcumin results in increased expression of POU5F1 proteinPMID:25822711 PMID:27237783
Pou5f1multiple interactionsISOPOU5F1 (Homo sapiens)6480464CTDWWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 mRNA]; WWTR1 protein inhibits the reaction [Curcumin results in decreased expression of POU5F1 protein]PMID:33539684
Pou5f1multiple interactionsISOPou5f1 (Mus musculus)6480464CTD2-methoxyestradiol inhibits the reaction [Curcumin results in increased expression of POU5F1 mRNA]PMID:25822711
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