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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962 Species: Homo sapiens RGD Object: Gene Symbol: CYP3A4 Name: cytochrome P450, family 3, subfamily A, polypeptide 4

Acc ID: CHEBI:63631 Term: topiramate Definition: A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine. CasRN: 97240-79-4 Chemical ID: MESH:C052342

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases activity	EXP		6480464	CTD	topiramate results in increased activity of CYP3A4 protein	PMID:14636322
increases expression	EXP		6480464	CTD	topiramate results in increased expression of CYP3A4 mRNA topiramate results in increased expression of CYP3A4 protein	PMID:14636322