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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962 Species: Homo sapiens RGD Object: Gene Symbol: CYP3A4 Name: cytochrome P450, family 3, subfamily A, polypeptide 4

Acc ID: CHEBI:39096 Term: alpha-hexachlorocyclohexane Definition: A hexachlorocyclohexane that has formula C6H6Cl6. CasRN: 319-84-6 Chemical ID: MESH:C040534

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:708379	6480464	CTD	[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of CYP3A2 mRNA [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 mRNA	PMID:16246485
multiple interactions	ISO	RGD:708379	6480464	CTD	[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP3A2 protein	PMID:11165752
increases expression	ISO	RGD:708379	6480464	CTD	alpha-hexachlorocyclohexane results in increased expression of CYP3A2 mRNA	PMID:16940010
multiple interactions	ISO	RGD:708379	6480464	CTD	[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 protein	PMID:11165752 PMID:16246485
multiple interactions	ISO	RGD:708379	6480464	CTD	[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 protein	PMID:16246485 PMID:11165752