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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962 Species: Homo sapiens RGD Object: Gene Symbol: CYP3A4 Name: cytochrome P450, family 3, subfamily A, polypeptide 4

Acc ID: CHEBI:29069 Term: phthalic acid Definition: A benzenedicarboxylic acid that has formula C8H6O4. CasRN: 88-99-3 Chemical ID: MESH:C032279

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	EXP		6480464	CTD	phthalic acid results in increased expression of CYP3A4 mRNA phthalic acid results in increased expression of CYP3A4 protein	PMID:15650019
multiple interactions	EXP		6480464	CTD	[CYP3A4 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid	PMID:22186153
multiple interactions	ISO	RGD:708379	6480464	CTD	[CYP3A2 protein results in increased metabolism of mono-(2-ethylhexyl)phthalate] which results in increased chemical synthesis of phthalic acid	PMID:22186153