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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962 Species: Homo sapiens RGD Object: Gene Symbol: CYP3A4 Name: cytochrome P450, family 3, subfamily A, polypeptide 4

Acc ID: CHEBI:17650 Term: cortisol Definition: Cortisol is a corticosteroid hormone or glucocorticoid produced by zona fasciculata of the adrenal cortex, which is a part of the adrenal gland. It is usually referred to as the 'stress hormone' as it is involved in response to stress and anxiety, controlled by corticotropin-releasing hormone (CRH). It increases blood pressure and blood sugar, and reduces immune responses CasRN: 50-23-7 Chemical ID: MESH:D006854

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
affects metabolic processing	EXP		6480464	CTD	CYP3A4 protein affects the metabolism of Hydrocortisone	PMID:15025748 PMID:16024008 PMID:15941677
increases metabolic processing	EXP		6480464	CTD	CYP3A4 protein results in increased metabolism of Hydrocortisone	PMID:11907490
affects hydroxylation	EXP		6480464	CTD	CYP3A4 protein affects the hydroxylation of Hydrocortisone	PMID:2271712
multiple interactions	EXP		6480464	CTD	CYP3A4 promoter mutant form inhibits the reaction [Hydrocortisone results in increased expression of CYP3A4 mRNA]	PMID:12505310
increases expression	EXP		6480464	CTD	Hydrocortisone results in increased expression of CYP3A4 mRNA	PMID:12505310
multiple interactions	EXP		6480464	CTD	kaempferol inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone] Quercetin inhibits the reaction [CYP3A4 protein results in increased degradation of Hydrocortisone]	PMID:15266218
affects metabolic processing	EXP		6480464	CTD	CYP3A4 protein affects the metabolism of Hydrocortisone	PMID:15941677 PMID:16024008 PMID:15025748
affects metabolic processing	EXP		6480464	CTD	CYP3A4 protein affects the metabolism of Hydrocortisone	PMID:16024008 PMID:15941677 PMID:15025748
multiple interactions	EXP		6480464	CTD	CYP3A4 promoter mutant form inhibits the reaction [Hydrocortisone results in increased expression of CYP3A4 mRNA]	PMID:12505310 PMID:12505310
affects metabolic processing	EXP		6480464	CTD	CYP3A4 protein affects the metabolism of Hydrocortisone	PMID:15941677 PMID:15025748 PMID:16024008
affects metabolic processing	EXP		6480464	CTD	CYP3A4 protein affects the metabolism of Hydrocortisone	PMID:15025748 PMID:15941677 PMID:16024008
increases expression	ISO	RGD:708379	6480464	CTD	Hydrocortisone results in increased expression of CYP3A2 mRNA	PMID:10476907