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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352962 Species: Homo sapiens RGD Object: Gene Symbol: CYP3A4 Name: cytochrome P450, family 3, subfamily A, polypeptide 4

Acc ID: CHEBI:16227 Term: pyridine Definition: The parent compound of the pyridines, comprising a benzene core in which one -CH group is replaced by a nitrogen atom. CasRN: 110-86-1 Chemical ID: MESH:C023666

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:708379	6480464	CTD	cordycepin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA] Dactinomycin inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA] Cycloheximide inhibits the reaction [pyridine results in increased expression of CYP3A2 mRNA]	PMID:11181506
increases activity	ISO	RGD:708379	6480464	CTD	pyridine results in increased activity of CYP3A2 protein	PMID:11181506
increases expression	ISO	RGD:708379	6480464	CTD	pyridine results in increased expression of CYP3A2 mRNA pyridine results in increased expression of CYP3A2 protein	PMID:11181506