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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352552 Species: Homo sapiens RGD Object: Gene Symbol: HAVCR1 Name: hepatitis A virus cellular receptor 1

Acc ID: CHEBI:27899 Term: cisplatin Definition: A platinum-containing anticancer drug that interacts with, and forms cross-links between, DNA and proteins. It is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. CasRN: 15663-27-1 Chemical ID: MESH:D002945

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1553522	6480464	CTD	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased expression of HAVCR1 protein]]	PMID:21593185
increases activity	ISO	RGD:1553522	6480464	CTD	Cisplatin results in increased activity of HAVCR1 mRNA	PMID:20702592
affects activity	ISO	RGD:1553522	6480464	CTD	Cisplatin affects the activity of HAVCR1	PMID:21835770
increases expression	ISO	RGD:1553522	6480464	CTD	Cisplatin results in increased expression of HAVCR1 mRNA	PMID:21616140
decreases expression	ISO	RGD:708425	6480464	CTD	Cisplatin results in decreased expression of HAVCR1 mRNA	PMID:22023808
multiple interactions	ISO	RGD:1553522	6480464	CTD	salubrinal promotes the reaction [Cisplatin results in increased expression of HAVCR1 mRNA]	PMID:21616140
increases expression	ISO	RGD:1553522	6480464	CTD	Cisplatin results in increased expression of HAVCR1 protein	PMID:21593185
increases expression	ISO	RGD:708425	6480464	CTD	Cisplatin results in increased expression of HAVCR1 mRNA	PMID:15033597 PMID:18289764 PMID:19839026 PMID:21795690
increases expression	ISO	RGD:708425	6480464	CTD	Cisplatin results in increased expression of HAVCR1 protein	PMID:15033597 PMID:19839026
increases expression	ISO	RGD:708425	6480464	CTD	Cisplatin results in increased expression of HAVCR1 mRNA	PMID:18289764 PMID:21795690 PMID:15033597 PMID:19839026
increases expression	ISO	RGD:708425	6480464	CTD	Cisplatin results in increased expression of HAVCR1 mRNA	PMID:21795690 PMID:18289764 PMID:19839026 PMID:15033597
increases expression	ISO	RGD:708425	6480464	CTD	Cisplatin results in increased expression of HAVCR1 mRNA	PMID:15033597 PMID:21795690 PMID:18289764 PMID:19839026
increases secretion	ISO	RGD:708425	6480464	CTD	Cisplatin results in increased secretion of HAVCR1 protein	PMID:20438795
increases expression	ISO	RGD:708425	6480464	CTD	Cisplatin results in increased expression of HAVCR1 protein	PMID:19839026 PMID:15033597
increases expression	ISO	RGD:708425	6480464	CTD	Cisplatin results in increased expression of HAVCR1 protein	PMID:15033597 PMID:19535489 PMID:19839026
increases expression	ISO	RGD:708425	6480464	CTD	Cisplatin results in increased expression of HAVCR1 mRNA	PMID:15033597 PMID:18289764 PMID:19839026 PMID:21795690 PMID:23142791