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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1351828 Species: Homo sapiens RGD Object: Gene Symbol: SLC22A3 Name: solute carrier family 22 (extraneuronal monoamine transporter), member 3

Acc ID: CHEBI:641 Term: N-methyl-4-phenylpyridinium Definition: A pyridinium ion having a phenyl substituent at the 4-position. CasRN: 48134-75-4 Chemical ID: MESH:D015655

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] BU 224 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] disprocynium 24 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] clobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Phentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] thioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] trimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]	PMID:12411423
multiple interactions	EXP		6480464	CTD	Famotidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium] Famotidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Metformin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Quinidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Ranitidine inhibits the reaction [SLC22A3 protein affects the transport of 1-Methyl-4-phenylpyridinium] Ranitidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Tetraethylammonium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]	PMID:16141367
increases uptake	EXP		6480464	CTD	SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium	PMID:16141367 PMID:12411423
multiple interactions	ISO	RGD:3701	6480464	CTD	BU 224 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] clobenpropit inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] 4-(1H-imidazol-4-ylmethyl)piperidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] disprocynium 24 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Histamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Papaverine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Phentolamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] thioperamide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] trimazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]	PMID:12411423
increases uptake	ISO	RGD:3701	6480464	CTD	SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium	PMID:12411423
increases uptake	EXP		6480464	CTD	SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium	PMID:12411423 PMID:16141367
multiple interactions	EXP		6480464	CTD	atorvastatin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Digoxin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Flecainide inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Ipratropium inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Lidocaine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Molsidomine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Nifedipine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Propafenone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Propranolol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Spironolactone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]	PMID:21641380
multiple interactions	EXP		6480464	CTD	carvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]	PMID:21641380 PMID:21697722
multiple interactions	EXP		6480464	CTD	Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]	PMID:21697722
increases uptake	EXP		6480464	CTD	SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium	PMID:12411423 PMID:16141367 PMID:21697722
multiple interactions	EXP		6480464	CTD	Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]	PMID:21697722 PMID:21641380
increases uptake	EXP		6480464	CTD	SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium	PMID:21697722 PMID:12411423 PMID:16141367 PMID:12110607
multiple interactions	EXP		6480464	CTD	Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]	PMID:12411423 PMID:12110607
multiple interactions	EXP		6480464	CTD	Estradiol inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] metiprenaline inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Phenoxybenzamine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Prazosin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] Progesterone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] SK&F 550 inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] pseudoisocyanine inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]	PMID:12110607
increases uptake	EXP		6480464	CTD	SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium	PMID:21697722 PMID:16141367 PMID:12411423 PMID:12110607
multiple interactions	EXP		6480464	CTD	Corticosterone inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]	PMID:12110607 PMID:12411423
increases uptake	EXP		6480464	CTD	SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium	PMID:12110607 PMID:12411423 PMID:16141367 PMID:21697722
affects uptake	EXP		6480464	CTD	SLC22A3 protein polymorphism affects the uptake of 1-Methyl-4-phenylpyridinium	PMID:20562519
increases transport	ISO	RGD:3701	6480464	CTD	SLC22A3 protein results in increased transport of 1-Methyl-4-phenylpyridinium	PMID:22543277