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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350540 Species: Homo sapiens RGD Object: Gene Symbol: CYP17A1 Name: cytochrome P450, family 17, subfamily A, polypeptide 1

Acc ID: CHEBI:5132 Term: flutamide Definition: A monocarboxylic acid amide that has formula C11H11F3N2O3. CasRN: 13311-84-7 Chemical ID: MESH:D005485

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
increases expression	ISO	RGD:737222	6480464	CTD	Flutamide results in increased expression of CYP17A1 mRNA	PMID:11509743
increases expression	ISO	RGD:2456	6480464	CTD	Flutamide results in increased expression of CYP17A1 mRNA	PMID:21525395 PMID:14967917
increases expression	ISO	RGD:2456	6480464	CTD	Flutamide results in increased expression of CYP17A1 mRNA	PMID:14967917 PMID:19299419 PMID:21525395
increases expression	ISO	RGD:2456	6480464	CTD	Flutamide results in increased expression of CYP17A1 mRNA	PMID:21525395 PMID:19299419 PMID:14967917
increases expression	ISO	RGD:2456	6480464	CTD	Flutamide results in increased expression of CYP17A1 mRNA	PMID:21525395 PMID:14967917 PMID:19299419