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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007 Species: Homo sapiens RGD Object: Gene Symbol: CYP2E1 Name: cytochrome P450, family 2, subfamily E, polypeptide 1

Acc ID: CHEBI:7789 Term: orphenadrine Definition: A tertiary amino compound which is the phenyl-o-tolylmethyl ether of 2-(dimethylamino)ethanol. CasRN: 83-98-7 Chemical ID: MESH:D009966

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	Orphenadrine inhibits the reaction [CYP2E1 protein results in increased chemical synthesis of 7-hydroxy-4-trifluoromethylcoumarin] Orphenadrine inhibits the reaction [CYP2E1 protein results in decreased ethylation of 7-ethoxy-4-trifluoromethylcoumarin]	PMID:9241656
decreases activity	EXP		6480464	CTD	Orphenadrine results in decreased activity of CYP2E1 protein	PMID:9241656