• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007 Species: Homo sapiens RGD Object: Gene Symbol: CYP2E1 Name: cytochrome P450, family 2, subfamily E, polypeptide 1

Acc ID: CHEBI:35176 Term: zinc sulfate Definition: A metal sulfate compound having zinc(2+) as the counterion. CasRN: 7733-02-0 Chemical ID: MESH:D019287

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:10451	6480464	CTD	[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	PMID:20118189
multiple interactions	ISO	RGD:10451	6480464	CTD	Zinc Sulfate inhibits the reaction [Ethanol results in increased activity of CYP2E1 protein] Zinc Sulfate inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]	PMID:15920153
multiple interactions	EXP		6480464	CTD	CYP2E1 results in increased susceptibility to [Arachidonic Acid co-treated with Zinc Sulfate] Zinc Sulfate inhibits the reaction [CYP2E1 results in increased susceptibility to Buthionine Sulfoximine] Zinc Sulfate inhibits the reaction [CYP2E1 results in increased susceptibility to Arachidonic Acid]	PMID:12566070
multiple interactions	ISO	RGD:2475	6480464	CTD	Paraquat promotes the reaction [Zinc Sulfate results in increased expression of CYP2E1 mRNA] Zinc Sulfate promotes the reaction [Paraquat results in increased expression of CYP2E1 mRNA]	PMID:20553223
increases expression	ISO	RGD:2475	6480464	CTD	Zinc Sulfate results in increased expression of CYP2E1 mRNA	PMID:20553223