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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344832 Species: Homo sapiens RGD Object: Gene Symbol: TNFSF10 Name: tumor necrosis factor (ligand) superfamily, member 10

Acc ID: CHEBI:4305 Term: dacarbazine Definition: A monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma. CasRN: 4342-03-4 Chemical ID: MESH:D003606

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP3 protein] TNFSF10 protein promotes the reaction [Dacarbazine results in increased cleavage of and results in increased activity of CASP8 protein]	PMID:17410615