• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332354 Species: Mus musculus RGD Object: Gene Symbol: Abca1 Name: ATP-binding cassette, sub-family A (ABC1), member 1

Acc ID: CHEBI:15365 Term: acetylsalicylic acid Definition: Benzoic acid carrying an acetoxy group at the 2-position. A non-steroidal anti-inflammatory drug with moA cyclooxygenase inhibitor activity. CasRN: 50-78-2 Chemical ID: MESH:D001241

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases expression	ISO	RGD:736157	6480464	CTD	Aspirin results in decreased expression of ABCA1 mRNA	PMID:15037193
increases expression	ISO	RGD:736157	6480464	CTD	Aspirin results in increased expression of ABCA1 mRNA Aspirin results in increased expression of ABCA1 protein	PMID:20137092
affects expression	EXP		6480464	CTD	Aspirin affects the expression of ABCA1 mRNA	PMID:21088444
multiple interactions	EXP		6480464	CTD	Aspirin affects the expression of and affects the activity of ABCA1 protein PPARA affects the reaction [Aspirin affects the expression of ABCA1 protein] PPARA affects the reaction [Aspirin affects the expression of ABCA1 mRNA]	PMID:21088444