Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
| multiple interactions | ISO | | 6480464 | CTD | [resveratrol co-treated with 1-Methyl-4-phenylpyridinium] results in increased expression of SIRT1 mRNA
| PMID:17583434
|
| increases expression | ISO | | 6480464 | CTD | resveratrol results in increased expression of SIRT1 mRNA
resveratrol results in increased expression of SIRT1 protein
| PMID:17583434
|
| multiple interactions | EXP | | 6480464 | CTD | SIRT1 protein promotes the reaction [resveratrol results in increased expression of ACADM mRNA]
SIRT1 protein promotes the reaction [resveratrol results in increased expression of PPARGC1A mRNA]
SIRT1 protein promotes the reaction [resveratrol results in increased expression of ESRRA mRNA]
| PMID:19934007
|
| multiple interactions | EXP | | 6480464 | CTD | [resveratrol results in increased activity of SIRT1 protein] which results in increased expression of DLG1 mRNA
| PMID:21232033
|
| multiple interactions | EXP | | 6480464 | CTD | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [TNF protein results in increased acetylation of RELA protein]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of IL6 protein]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of IL1B protein]]
| PMID:22069489
|
| increases expression | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased expression of SIRT1 protein
| PMID:16849586
PMID:19664641
PMID:19928762
PMID:20960276
PMID:21732533
PMID:21892612
PMID:22245592
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | [resveratrol binds to and results in increased activity of SIRT1 protein] which results in decreased activity of ATXN3 protein mutant form
| PMID:17885668
|
| increases activity | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:17103016
PMID:15749705
PMID:17327447
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | resveratrol promotes the reaction [SIRT1 protein binds to BIRC3 promoter]
| PMID:15152190
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | [resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of PARP1 protein
| PMID:16628003
|
| increases expression | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased expression of SIRT1 protein
| PMID:20960276
PMID:16849586
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of NOS3 mRNA]]
SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased secretion of Nitric Oxide]]]
SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of SELE mRNA]]
| PMID:20960276
|
| multiple interactions | EXP | | 6480464 | CTD | resveratrol inhibits the reaction [Cisplatin results in decreased expression of and results in decreased activity of SIRT1 protein]
SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in decreased expression of BCL2L1]]
SIRT1 mutant form inhibits the reaction [resveratrol inhibits the reaction [Cisplatin results in increased acetylation of TRP53 protein]]
| PMID:21593185
|
| multiple interactions | EXP | | 6480464 | CTD | resveratrol promotes the reaction [SIRT1 protein results in decreased acetylation of PPARGC1A protein]
| PMID:17581637
|
| increases activity | EXP | | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:17581637
PMID:17112576
|
| increases response to substance | EXP | | 6480464 | CTD | SIRT1 results in increased susceptibility to resveratrol
| PMID:21593185
|
| multiple interactions | EXP | | 6480464 | CTD | SIRT1 protein affects the reaction [resveratrol results in increased expression of MYH6 mRNA]
| PMID:18192211
|
| increases expression | ISO | RGD:1308542 | 6480464 | CTD | resveratrol results in increased expression of SIRT1 mRNA
resveratrol results in increased expression of SIRT1 protein
| PMID:17583434
|
| multiple interactions | ISO | RGD:1308542 | 6480464 | CTD | [resveratrol co-treated with 1-Methyl-4-phenylpyridinium] results in increased expression of SIRT1 mRNA
| PMID:17583434
|
| increases activity | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:17103016
PMID:17327447
PMID:15749705
|
| increases activity | EXP | | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:17112576
PMID:17581637
|
| increases expression | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased expression of SIRT1 protein
| PMID:16849586
PMID:20960276
|
| increases activity | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:17327447
PMID:17103016
PMID:15749705
|
| multiple interactions | ISO | RGD:1308542 | 6480464 | CTD | resveratrol inhibits the reaction [Dietary Fats results in decreased activity of SIRT1 protein]
| PMID:21632075
|
| increases expression | ISO | RGD:1308542 | 6480464 | CTD | resveratrol results in increased expression of SIRT1 mRNA
resveratrol results in increased expression of SIRT1 protein
| PMID:17583434
PMID:21715682
PMID:22357324
|
| decreases expression | ISO | RGD:1308542 | 6480464 | CTD | resveratrol results in decreased expression of SIRT1 protein
| PMID:20195491
|
| increases activity | ISO | RGD:1308542 | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:18077353
PMID:19008341
PMID:20429690
|
| multiple interactions | ISO | RGD:1308542 | 6480464 | CTD | [resveratrol results in increased activity of SIRT1 protein] which results in increased acetylation of and results in decreased degradation of FOXO1 protein
| PMID:18077353
|
| multiple interactions | ISO | RGD:1308542 | 6480464 | CTD | resveratrol promotes the reaction [Tobacco Smoke Pollution results in increased expression of SIRT1 mRNA]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Hydrogen Peroxide]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased activity of CASP3 protein]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Superoxides]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased activity of CASP7 protein]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of NOS2 mRNA]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF mRNA]]
| PMID:18424637
|
| affects response to substance | ISO | RGD:1308542 | 6480464 | CTD | SIRT1 protein affects the susceptibility to resveratrol
| PMID:20651248
|
| multiple interactions | ISO | RGD:1308542 | 6480464 | CTD | resveratrol binds to and results in increased activity of SIRT1 protein
| PMID:18239056
PMID:22968147
|
| increases activity | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:15749705
PMID:17103016
PMID:17327447
|
| increases response to substance | EXP | | 6480464 | CTD | SIRT1 protein results in increased susceptibility to resveratrol
| PMID:22069489
|
| multiple interactions | ISO | | 6480464 | CTD | resveratrol inhibits the reaction [Palmitic Acid results in decreased expression of SIRT1 mRNA]
| PMID:22968147
|
| multiple interactions | ISO | | 6480464 | CTD | resveratrol binds to and results in increased activity of SIRT1 protein
| PMID:18239056
PMID:22968147
|
| multiple interactions | ISO | | 6480464 | CTD | [resveratrol results in increased activity of SIRT1 protein] which results in increased acetylation of and results in decreased degradation of FOXO1 protein
| PMID:18077353
|
| increases activity | ISO | | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:18077353
PMID:19008341
PMID:20429690
|
| multiple interactions | ISO | | 6480464 | CTD | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in decreased expression of AGTR1 mRNA]
| PMID:18420994
|
| increases expression | ISO | | 6480464 | CTD | resveratrol results in increased expression of SIRT1 mRNA
resveratrol results in increased expression of SIRT1 protein
| PMID:17583434
PMID:21715682
PMID:22357324
|
| increases expression | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased expression of SIRT1
| PMID:21224254
PMID:21238464
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | SIRT1 protein promotes the reaction [resveratrol results in decreased expression of and results in decreased secretion of IL6 protein]
SIRT1 protein promotes the reaction [resveratrol results in decreased expression of and results in decreased secretion of IL8 protein]
| PMID:20463039
|
| multiple interactions | EXP | | 6480464 | CTD | resveratrol inhibits the reaction [Lipopolysaccharides results in decreased activity of SIRT1 protein]
| PMID:19279313
|
| increases activity | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:15749705
PMID:17103016
PMID:17327447
PMID:18482975
PMID:19047049
PMID:19071085
PMID:19288225
PMID:20097879
PMID:20169165
PMID:20426787
PMID:20844277
PMID:20978007
PMID:21713995
PMID:21745208
PMID:22245592
PMID:22990594
|
| increases activity | EXP | | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:17112576
PMID:17581637
PMID:19819963
PMID:19934007
PMID:20561979
PMID:21321189
PMID:22659145
|
| increases expression | EXP | | 6480464 | CTD | resveratrol results in increased expression of SIRT1 mRNA
| PMID:18755807
PMID:22945685
|
| increases expression | EXP | | 6480464 | CTD | resveratrol results in increased expression of SIRT1
| PMID:21224254
|
| increases expression | EXP | | 6480464 | CTD | resveratrol results in increased expression of SIRT1 protein
| PMID:18930334
PMID:19940103
PMID:22309033
PMID:22878646
PMID:23090186
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP1 protein]]
[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [IL1B protein results in increased expression of MMP3 protein]
| PMID:20426787
|
| multiple interactions | ISO | RGD:1308542 | 6480464 | CTD | resveratrol inhibits the reaction [Palmitic Acid results in decreased expression of SIRT1 mRNA]
| PMID:22968147
|
| increases activity | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:15749705
PMID:17103016
PMID:17327447
PMID:22245592
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | [resveratrol results in increased activity of SIRT1 protein] which results in decreased expression of CTNNB1 protein
[resveratrol results in increased activity of SIRT1 protein] which results in decreased expression of EGLN1 protein
[resveratrol results in increased activity of SIRT1 protein] which results in decreased expression of MYC protein
[resveratrol results in increased activity of SIRT1 protein] which results in increased expression of HIF1A protein
| PMID:22245592
|
| increases expression | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased expression of SIRT1 protein
| PMID:16849586
PMID:20960276
PMID:22245592
|
| multiple interactions | EXP | | 6480464 | CTD | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein]
[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of BAD protein]
[resveratrol results in increased activity of SIRT1 protein] which results in decreased cleavage of and results in decreased activity of CASP3 protein
[resveratrol results in increased activity of SIRT1 protein] which results in decreased localization of FOXO3 protein
[resveratrol results in increased activity of SIRT1 protein] which results in decreased cleavage of and results in decreased activity of CASP1 protein
[[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in decreased activity of FOXO3 protein] which results in decreased susceptibility to Glucose
[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in increased activity of AKT1 protein
resveratrol results in increased localization of and results in increased activity of SIRT1 protein
[resveratrol results in increased localization of and results in increased activity of SIRT1 protein] which results in decreased susceptibility to Glucose
| PMID:20370652
|
| multiple interactions | ISO | RGD:1308542 | 6480464 | CTD | [Niacinamide results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in decreased expression of AGTR1 mRNA]
| PMID:18420994
|
| multiple interactions | EXP | | 6480464 | CTD | resveratrol inhibits the reaction [Streptozocin results in decreased activity of SIRT1 protein]
| PMID:22058332
|
| increases expression | EXP | | 6480464 | CTD | resveratrol results in increased expression of SIRT1 protein
| PMID:18930334
PMID:19940103
PMID:22878646
PMID:23090186
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | resveratrol promotes the reaction [SIRT1 protein binds to FOXO3A protein]
resveratrol promotes the reaction [[SIRT1 protein binds to FOXO3A protein] which binds to RUNX2 3' UTR]
resveratrol promotes the reaction [[[SIRT1 protein binds to FOXO3A protein] which binds to RUNX2 3' UTR] which results in increased expression of RUNX2 mRNA]
[resveratrol results in increased activity of SIRT1 protein] which results in increased expression of FOXO3A protein
| PMID:21713995
|
| decreases expression | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in decreased expression of SIRT1 mRNA
| PMID:21980390
|
| increases activity | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:15749705
PMID:17103016
PMID:17327447
PMID:21713995
PMID:22245592
|
| increases expression | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased expression of SIRT1
| PMID:21238464
|
| increases expression | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased expression of SIRT1 protein
| PMID:16849586
PMID:20960276
PMID:21892612
PMID:22245592
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | [resveratrol results in increased expression of SIRT1] which results in decreased expression of MMP9
| PMID:21238464
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Glucose results in increased acetylation of TP53 protein]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Palmitates results in increased acetylation of TP53 protein]]
| PMID:20068143
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | SIRT1 protein promotes the reaction [resveratrol results in increased expression of KLF2 mRNA]
| PMID:19815564
|
| multiple interactions | EXP | | 6480464 | CTD | resveratrol inhibits the reaction [Dextran Sulfate results in decreased expression of SIRT1 protein]
| PMID:19940103
|
| multiple interactions | EXP | | 6480464 | CTD | resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]
wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]
| PMID:22952890
|
| multiple interactions | EXP | | 6480464 | CTD | resveratrol inhibits the reaction [Nicotine results in decreased expression of SIRT1 mRNA]
| PMID:22687363
|
| increases activity | EXP | | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:17112576
PMID:17581637
PMID:20561979
|
| multiple interactions | EXP | | 6480464 | CTD | [resveratrol results in increased activity of SIRT1 protein] which results in increased expression of PPARGC1A protein
| PMID:20561979
|
| increases expression | EXP | | 6480464 | CTD | resveratrol results in increased expression of SIRT1 mRNA
| PMID:18755807
|
| increases expression | EXP | | 6480464 | CTD | resveratrol results in increased expression of SIRT1 protein
| PMID:19940103
|
| multiple interactions | EXP | | 6480464 | CTD | Ethanol promotes the reaction [resveratrol results in increased expression of SIRT1 protein]
[resveratrol co-treated with Ethanol] results in increased expression of SIRT1 mRNA
resveratrol inhibits the reaction [Ethanol results in decreased activity of SIRT1 protein]
resveratrol inhibits the reaction [[Ethanol results in decreased activity of SIRT1 protein] which results in increased acetylation of PPARGC1A protein]
resveratrol inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA]
[resveratrol results in increased activity of SIRT1 protein] which results in decreased acetylation of PPARGC1A protein
resveratrol results in increased expression of and results in increased activity of SIRT1 protein
| PMID:18755807
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | Niacinamide inhibits the reaction [resveratrol results in increased expression of SIRT1 protein]
[resveratrol results in increased abundance of NAD] which results in increased expression of SIRT1 protein
| PMID:19928762
|
| multiple interactions | EXP | | 6480464 | CTD | resveratrol promotes the reaction [SIRT1 protein results in increased acetylation of TRP53 protein]
| PMID:19819963
|
| increases activity | EXP | | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:17112576
PMID:17581637
PMID:19819963
PMID:20561979
PMID:21321189
|
| multiple interactions | ISO | | 6480464 | CTD | resveratrol inhibits the reaction [Dietary Fats results in decreased activity of SIRT1 protein]
| PMID:21632075
|
| decreases expression | ISO | | 6480464 | CTD | resveratrol results in decreased expression of SIRT1 protein
| PMID:20195491
|
| increases expression | ISO | | 6480464 | CTD | resveratrol results in increased expression of SIRT1 mRNA
resveratrol results in increased expression of SIRT1 protein
| PMID:17583434
PMID:21715682
|
| affects response to substance | ISO | | 6480464 | CTD | SIRT1 protein affects the susceptibility to resveratrol
| PMID:20651248
|
| decreases expression | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in decreased expression of SIRT1 protein
| PMID:20195491
|
| increases activity | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased activity of SIRT1 protein
| PMID:15749705
PMID:17103016
PMID:17327447
PMID:18482975
PMID:19047049
PMID:19288225
PMID:20097879
PMID:20169165
PMID:20844277
PMID:20978007
PMID:21713995
PMID:21745208
PMID:22245592
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | [resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein
[[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein
[resveratrol results in increased activity of SIRT1 protein] which results in decreased phosphorylation of EIF4EBP1 protein
[resveratrol results in increased activity of SIRT1 protein] which results in decreased phosphorylation of RPS6 protein
TSC2 protein promotes the reaction [[[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6 protein]
| PMID:20169165
|
| increases expression | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased expression of SIRT1 mRNA
| PMID:20697895
|
| increases expression | ISO | RGD:1318374 | 6480464 | CTD | resveratrol results in increased expression of SIRT1 protein
| PMID:16849586
PMID:19664641
PMID:19928762
PMID:20960276
PMID:21892612
PMID:22245592
|
| affects response to substance | ISO | RGD:1318374 | 6480464 | CTD | SIRT1 protein affects the susceptibility to resveratrol
| PMID:22523472
|
| affects response to substance | EXP | | 6480464 | CTD | SIRT1 protein affects the susceptibility to resveratrol
| PMID:23090186
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | [sirtinol results in decreased activity of SIRT1 protein] which results in decreased susceptibility to resveratrol
| PMID:20610621
PMID:20697895
|
| increases response to substance | ISO | RGD:1318374 | 6480464 | CTD | SIRT1 protein results in increased susceptibility to resveratrol
| PMID:19664641
|
| multiple interactions | EXP | | 6480464 | CTD | PRKAA1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]]
PRKAA2 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]]
[SIRT1 protein co-treated with resveratrol] affects the reaction [Glucose affects the expression of PPARGC1A protein]
| PMID:23090186
|
| multiple interactions | EXP | | 6480464 | CTD | [resveratrol co-treated with Oxygen deficiency] results in increased expression of SIRT1 mRNA
| PMID:21113404
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein inhibits the reaction [resveratrol promotes the reaction [Glucose results in increased secretion of INS protein]]]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of GCK mRNA]]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of PDX1 mRNA]]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of SLC2A2 mRNA]]
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [SIRT1 protein promotes the reaction [resveratrol results in increased expression of TFAM mRNA]]
| PMID:21163946
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | resveratrol promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein]
[resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein]
[[resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein]] which results in decreased acetylation of and results in decreased activity of RELA protein
[[resveratrol results in increased activity of SIRT1 protein] promotes the reaction [SIRT1 protein binds to and results in decreased activity of EP300 protein]] which results in decreased acetylation of and results in decreased activity of CTNNB1 protein
| PMID:19047049
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [TNF protein results in increased expression of F3 mRNA]
[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [TNF protein results in increased expression of F3 protein]
| PMID:20978007
|
| multiple interactions | EXP | | 6480464 | CTD | [resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein
[[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of EIF4EBP1 protein
[[resveratrol results in increased activity of SIRT1 protein] which results in decreased activity of MTOR protein] which results in decreased phosphorylation of RPS6KB1 protein
| PMID:21321189
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein]
[resveratrol results in increased activity of SIRT1 protein] which results in decreased susceptibility to Hydrogen Peroxide
| PMID:18681908
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | [resveratrol co-treated with Lipopolysaccharides] results in increased expression of SIRT1 mRNA
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased secretion of IL8 protein]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprostone]]
| PMID:20844277
|
| multiple interactions | ISO | RGD:1318374 | 6480464 | CTD | [resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]
[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [[Glucose results in increased expression of FASN protein] which results in increased abundance of Triglycerides]
[resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]
[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in increased activity of PRKAA1 protein
[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of and results in increased activity of PRKAA2 protein
SIRT1 protein promotes the reaction [[resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA2 protein]] which results in decreased abundance of Triglycerides]
SIRT1 protein promotes the reaction [resveratrol results in increased phosphorylation of ACC1 protein]
SIRT1 protein promotes the reaction [resveratrol results in increased phosphorylation of PRKAA2 protein]
[splitomicin results in decreased activity of SIRT1 protein] inhibits the reaction [resveratrol results in increased phosphorylation of ACACA protein]
STK11 protein promotes the reaction [[resveratrol results in increased activity of SIRT1 protein] which results in increased phosphorylation of PRKAA2 protein]
| PMID:18482975
|
| multiple interactions | ISO | | 6480464 | CTD | resveratrol promotes the reaction [Tobacco Smoke Pollution results in increased expression of SIRT1 mRNA]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Hydrogen Peroxide]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased abundance of Superoxides]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased activity of CASP3 protein]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased activity of CASP7 protein]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of IL6 mRNA]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of NOS2 mRNA]]
SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [Tobacco Smoke Pollution results in increased expression of TNF mRNA]]
| PMID:18424637
|
