• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315043 Species: Homo sapiens RGD Object: Gene Symbol: MAP3K5 Name: mitogen-activated protein kinase kinase kinase 5

Acc ID: CHEBI:34905 Term: paraquat Definition: An organic cation that consists of 4,4'-bipyridine bearing two N-methyl substituents loctated at the 1- and 1'-positions. CasRN: 4685-14-7 Chemical ID: MESH:D010269

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	EXP		6480464	CTD	[Paraquat co-treated with MAP3K5 protein] results in increased degradation of SQSTM1 protein [Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein Paraquat promotes the reaction [MAP3K5 protein results in increased phosphorylation of ERN1 protein] salubrinal affects the susceptibility to [Paraquat co-treated with MAP3K5 protein] salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased degradation of SQSTM1 protein] salubrinal promotes the reaction [[Paraquat co-treated with MAP3K5 protein] results in increased expression of BECN1 protein]	PMID:20929985
multiple interactions	EXP		6480464	CTD	Paraquat results in increased phosphorylation of and results in increased activity of MAP3K5 protein salubrinal inhibits the reaction [Paraquat results in increased phosphorylation of and results in increased activity of MAP3K5 protein]	PMID:19735704