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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1314953 Species: Homo sapiens RGD Object: Gene Symbol: MGST3 Name: microsomal glutathione S-transferase 3

Acc ID: CHEBI:32509 Term: pirinixic acid Definition: An aryl sulfide that has formula C14H14ClN3O2S. CasRN: 50892-23-4 Chemical ID: MESH:C006253

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1314954	6480464	CTD	[pirinixic acid co-treated with PPARA] results in increased expression of MGST3 mRNA	PMID:20813756
increases expression	ISO	RGD:1314954	6480464	CTD	pirinixic acid results in increased expression of MGST3 mRNA	PMID:20813756 PMID:16221962 PMID:17426115 PMID:11798191 PMID:18301758
multiple interactions	EXP		6480464	CTD	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of MGST3 mRNA	PMID:19710929
increases expression	ISO	RGD:1314954	6480464	CTD	pirinixic acid results in increased expression of MGST3 mRNA	PMID:18301758 PMID:20813756 PMID:11798191 PMID:16221962 PMID:17426115
increases expression	ISO	RGD:1314954	6480464	CTD	pirinixic acid results in increased expression of MGST3 mRNA	PMID:16221962 PMID:18301758 PMID:11798191 PMID:17426115 PMID:20813756
increases expression	ISO	RGD:1314954	6480464	CTD	pirinixic acid results in increased expression of MGST3 mRNA	PMID:20813756 PMID:11798191 PMID:18301758 PMID:16221962 PMID:17426115
increases expression	ISO	RGD:1314954	6480464	CTD	pirinixic acid results in increased expression of MGST3 mRNA	PMID:20813756 PMID:17426115 PMID:11798191 PMID:16221962 PMID:18301758
increases expression	ISO	RGD:1314954	6480464	CTD	pirinixic acid results in increased expression of MGST3 mRNA	PMID:18301758 PMID:17426115 PMID:16221962 PMID:20813756 PMID:11798191
increases expression	ISO	RGD:1314954	6480464	CTD	pirinixic acid results in increased expression of MGST3 mRNA	PMID:11798191 PMID:16221962 PMID:17426115 PMID:18301758 PMID:20813756