• View As List
• View As Table

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1313299 Species: Homo sapiens RGD Object: Gene Symbol: MDM2 Name: MDM2 oncogene, E3 ubiquitin protein ligase

Acc ID: CHEBI:46195 Term: paracetamol Definition: A derivative of phenol which has an acetamido substituent located para to the phenolic -OH group. CasRN: 103-90-2 Chemical ID: MESH:D000082

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1313300	6480464	CTD	[Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of MDM2 mRNA]	PMID:17585979
affects expression	ISO	RGD:1313300	6480464	CTD	Acetaminophen affects the expression of MDM2 mRNA	PMID:17562736
multiple interactions	ISO	RGD:1305332	6480464	CTD	Acetaminophen promotes the reaction [MDM2 protein binds to TP53 protein]	PMID:16330492
increases expression	ISO	RGD:1305332	6480464	CTD	Acetaminophen results in increased expression of MDM2 mRNA	PMID:17202762
increases phosphorylation	ISO	RGD:1305332	6480464	CTD	Acetaminophen results in increased phosphorylation of MDM2 protein	PMID:16330492
decreases expression	EXP		6480464	CTD	Acetaminophen results in decreased expression of MDM2 mRNA	PMID:21420995
decreases expression	ISO	RGD:1305332	6480464	CTD	Acetaminophen results in decreased expression of MDM2 mRNA	PMID:21807079
increases expression	EXP		6480464	CTD	Acetaminophen results in increased expression of MDM2 mRNA	PMID:22230336