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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1310320 Species: Rattus norvegicus RGD Object: Gene Symbol: Tmem177 Name: transmembrane protein 177

Acc ID: CHEBI:64090 Term: tert-butyl hydroperoxide Definition: An alkyl hydroperoxide in which the alkyl group is tert-butyl. It is widely used in a variety of oxidation processes. CasRN: 75-91-2 Chemical ID: MESH:D020122

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1606772	6480464	CTD	[pioglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of TMEM177 mRNA [rosiglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of TMEM177 mRNA [troglitazone co-treated with tert-Butylhydroperoxide] results in decreased expression of TMEM177 mRNA troglitazone inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of TMEM177 mRNA]	PMID:20847119
increases expression	ISO	RGD:1606772	6480464	CTD	tert-Butylhydroperoxide results in increased expression of TMEM177 mRNA	PMID:15336504
decreases expression	ISO	RGD:1606772	6480464	CTD	tert-Butylhydroperoxide results in decreased expression of TMEM177 mRNA	PMID:20847119