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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309952
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mthfr
Name: methylenetetrahydrofolate reductase
Acc ID: CHEBI:47217
Term: arsane
Definition: An arsine that has formula 77.94542.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mthfraffects metabolic processingISOMTHFR (Homo sapiens)6480464CTDMTHFR gene polymorphism affects the metabolism of Arsenic; MTHFR polymorphism affects the metabolism of ArsenicPMID:17365577 PMID:17637926
Mthfraffects methylationISOMTHFR (Homo sapiens)6480464CTDMTHFR polymorphism affects the methylation of ArsenicPMID:17440589
Mthfraffects response to substanceISOMTHFR (Homo sapiens)6480464CTDMTHFR gene SNP affects the susceptibility to ArsenicPMID:31864032
Mthfrincreases response to substanceISOMTHFR (Homo sapiens)6480464CTDMTHFR gene SNP results in increased susceptibility to ArsenicPMID:22747749
Mthfrmultiple interactionsISOMTHFR (Homo sapiens)6480464CTDMTHFR gene polymorphism affects the metabolism of and affects the susceptibility to ArsenicPMID:17365577 PMID:17548696
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