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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309799
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac1
Name: histone deacetylase 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac1increases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of HDAC1 mRNAPMID:22493514 PMID:34747641
Hdac1decreases expressionISOHdac1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of HDAC1 mRNAPMID:24058054
Hdac1multiple interactionsISOHDAC1 (Homo sapiens)6480464CTD[IL1B protein co-treated with Tetrachlorodibenzodioxin] inhibits the reaction [HDAC1 protein binds to IL6 promoter]; [Tetrachlorodibenzodioxin co-treated with Estradiol] promotes the reaction [HDAC1 protein binds to BRCA1 promoter]; HDAC1 mutant form inhibits the reaction [[IL1B protein co-treated with Tetrachlorodibenzodioxin] results in increased expression of IL6 mRNA]; Tetrachlorodibenzodioxin promotes the reaction [HDAC1 protein binds to BRCA1 promoter]PMID:16489025 PMID:20511231
Hdac1multiple interactionsISOHdac1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HDAC1 mRNA; Tetrachlorodibenzodioxin affects the reaction [HDAC1 protein binds to CYP1A1 promoter]PMID:17652329 PMID:17942748
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