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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309799
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hdac1
Name: histone deacetylase 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hdac1decreases expressionISOHDAC1 (Homo sapiens)6480464CTDresveratrol results in decreased expression of HDAC1 proteinPMID:23593078
Hdac1increases expressionISOHdac1 (Mus musculus)6480464CTDresveratrol results in increased expression of HDAC1 mRNAPMID:22610192
Hdac1multiple interactionsISOHDAC1 (Homo sapiens)6480464CTD[[resveratrol results in decreased expression of MTA1 protein] inhibits the reaction [MTA1 protein binds to HDAC1 protein]] which results in increased acetylation of and results in increased activity of TP53 protein; [resveratrol results in decreased expression of MTA1 protein] inhibits the reaction [MTA1 protein binds to HDAC1 protein]; HDAC1 protein promotes the reaction [resveratrol results in decreased expression of ZBTB7A mRNA]; resveratrol inhibits the reaction [SP1 protein binds to HDAC1 protein]; resveratrol promotes the reaction [HDAC1 protein binds to SP1 protein]; resveratrol promotes the reaction [HDAC1 protein binds to ZBTB7A promoter]PMID:19810103 PMID:25875864
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