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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1309361
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col8a1
Name: collagen type VIII alpha 1 chain
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col8a1affects methylationISOCOL8A1 (Homo sapiens)6480464CTDBenzo(a)pyrene affects the methylation of COL8A1 5' UTRPMID:27901495
Col8a1decreases expressionISOCol8a1 (Mus musculus)6480464CTDBenzo(a)pyrene results in decreased expression of COL8A1 mRNAPMID:15034205 PMID:15894712
Col8a1increases expressionISOCOL8A1 (Homo sapiens)6480464CTDBenzo(a)pyrene results in increased expression of COL8A1 mRNAPMID:32234424
Col8a1increases expressionISOCol8a1 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of COL8A1 mRNAPMID:27195522
Col8a1multiple interactionsISOCol8a1 (Mus musculus)6480464CTD[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of COL8A1 mRNA; AHR protein promotes the reaction [Benzo(a)pyrene results in decreased expression of COL8A1 mRNA]PMID:15034205 PMID:15894712
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