GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt1 | increases expression | EXP | | 6480464 | CTD | Thioctic Acid results in increased expression of SIRT1 protein | PMID:22327056 | Sirt1 | multiple interactions | EXP | | 6480464 | CTD | [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of FOXO3 protein; [Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results in decreased acetylation of PPARGC1B protein; Thioctic Acid inhibits the reaction [Dietary Fats results in decreased expression of SIRT1 mRNA] | PMID:22327056 | Sirt1 | increases expression | ISO | Sirt1 (Mus musculus) | 6480464 | CTD | Thioctic Acid results in increased expression of SIRT1 mRNA | PMID:37739047 | Sirt1 | multiple interactions | ISO | Sirt1 (Mus musculus) | 6480464 | CTD | Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT1 mRNA] | PMID:37739047 | | ||||||||||||||||||||||
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