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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308542
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:28201
Term: rotenone
Definition: A member of the class of rotenones that consists of 1,2,12,12a-tetrahydrochromeno[3,4-b]furo[2,3-h]chromen-6(6aH)-one substituted at position 2 by a prop-1-en-2-yl group and at positions 8 and 9 by methoxy groups (the 2R,6aS,12aS-isomer). A non-systemic insecticide, it is the principal insecticidal constituent of derris (the dried rhizome and root of Derris elliptica).
Chemical ID: MESH:D012402
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1decreases expressionEXP 6480464CTDRotenone results in decreased expression of SIRT1 proteinPMID:18538940
Sirt1increases expressionEXP 6480464CTDRotenone results in increased expression of SIRT1 proteinPMID:18538940
Sirt1decreases expressionISOSIRT1 (Homo sapiens)6480464CTDRotenone results in decreased expression of SIRT1 mRNA; Rotenone results in decreased expression of SIRT1 proteinPMID:25991017 PMID:31926197
Sirt1multiple interactionsISOSIRT1 (Homo sapiens)6480464CTDpolydatin inhibits the reaction [Rotenone results in decreased expression of SIRT1 protein]; Resveratrol inhibits the reaction [Rotenone promotes the reaction [TP53 protein modified form binds to SIRT1 protein]]; Resveratrol inhibits the reaction [Rotenone results in decreased expression of SIRT1 mRNA]; Resveratrol inhibits the reaction [Rotenone results in decreased expression of SIRT1 protein]; Rotenone promotes the reaction [TP53 protein modified form binds to SIRT1 protein]PMID:25991017 PMID:31926197
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