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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308542
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1decreases activityEXP 6480464CTDEthanol results in decreased activity of SIRT1 proteinPMID:34470993
Sirt1decreases expressionEXP 6480464CTDEthanol results in decreased expression of SIRT1 mRNA; Ethanol results in decreased expression of SIRT1 proteinPMID:24769256 PMID:26854922 PMID:27989594 PMID:29940154 PMID:32087266 PMID:34470993
Sirt1increases expressionEXP 6480464CTDEthanol results in increased expression of SIRT1 mRNA; Ethanol results in increased expression of SIRT1 proteinPMID:18793633 PMID:32894639
Sirt1multiple interactionsEXP 6480464CTD3-(3,4-dimethoxyphenyl)propenoic acid inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA]; [Ethanol co-treated with Aflatoxin B1] results in increased expression of SIRT1 mRNA; [Ethanol co-treated with Aflatoxin B1] results in increased expression of SIRT1 protein; [Ethanol co-treated with Oleic Acid co-treated with Palmitic Acid] results in decreased expression of SIRT1 protein; [Niacinamide co-treated with Resveratrol] promotes the reaction [[Ethanol co-treated with Aflatoxin B1] results in increased expression of SIRT1 mRNA]; [Resveratrol co-treated with Niacinamide] promotes the reaction [[Ethanol co-treated with Aflatoxin B1] results in increased expression of SIRT1 protein]; N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide inhibits the reaction [Resveratrol inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA]]; N-(4-(1-benzoylpiperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide inhibits the reaction [Resveratrol inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]]; naringin inhibits the reaction [Ethanol results in increased expression of SIRT1 mRNA]; Nicotinamide Mononucleotide inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA]; Nicotinamide Mononucleotide inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]; Resveratrol inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA]; Resveratrol inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]; Resveratrol inhibits the reaction [Ethanol results in increased expression of SIRT1 mRNA]; Resveratrol promotes the reaction [[Ethanol co-treated with Aflatoxin B1] results in increased expression of SIRT1 mRNA]; Resveratrol promotes the reaction [[Ethanol co-treated with Aflatoxin B1] results in increased expression of SIRT1 protein]; salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA]; salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]; SIRT1 protein affects the reaction [Ethanol results in increased expression of MLXIPL protein]; SIRT1 protein affects the reaction [salvianolic acid B inhibits the reaction [Ethanol results in increased expression of MLXIPL protein]]; SIRT1 protein inhibits the reaction [Ethanol results in increased acetylation of and results in increased activity of SREBF1 protein]PMID:18239056 PMID:18793633 PMID:24769256 PMID:26854922 PMID:27989594 PMID:29940154 PMID:32087266 PMID:32894639
Sirt1decreases activityISOSirt1 (Mus musculus)6480464CTDEthanol results in decreased activity of SIRT1 proteinPMID:18239056
Sirt1decreases expressionISOSIRT1 (Homo sapiens)6480464CTDEthanol results in decreased expression of SIRT1 mRNA; Ethanol results in decreased expression of SIRT1 proteinPMID:24224909 PMID:27989594 PMID:29940154
Sirt1decreases expressionISOSirt1 (Mus musculus)6480464CTDEthanol results in decreased expression of SIRT1 mRNA; Ethanol results in decreased expression of SIRT1 proteinPMID:18755807 PMID:20007851 PMID:24095927 PMID:24892905 PMID:27688165 PMID:27984176 PMID:28964808
Sirt1multiple interactionsISOSIRT1 (Homo sapiens)6480464CTD3-(3,4-dimethoxyphenyl)propenoic acid inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA]; 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide promotes the reaction [Ethanol results in decreased expression of SIRT1 protein]; resveratrol inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]; salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]PMID:24224909 PMID:27989594 PMID:29940154
Sirt1multiple interactionsISOSirt1 (Mus musculus)6480464CTD5-aminoisoquinolinone inhibits the reaction [Ethanol results in decreased activity of SIRT1 protein]; 5-aminoisoquinolinone inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA]; [Ethanol results in decreased activity of SIRT1 protein] which results in increased acetylation of and results in increased localization of and results in increased activity of SREBF1 protein; [Ethanol results in decreased activity of SIRT1 protein] which results in increased acetylation of PPARGC1A protein; [Resveratrol co-treated with Ethanol] results in increased expression of SIRT1 mRNA; acanthoic acid inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]; Chlormethiazole inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]; Ethanol promotes the reaction [Resveratrol results in increased expression of SIRT1 protein]; Ethanol results in decreased expression of and results in decreased activity of SIRT1 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Ethanol results in decreased expression of and results in decreased activity of SIRT1 protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA]; Resveratrol inhibits the reaction [[Ethanol results in decreased activity of SIRT1 protein] which results in increased acetylation of PPARGC1A protein]; Resveratrol inhibits the reaction [Ethanol results in decreased activity of SIRT1 protein]; Resveratrol inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA]; Rosiglitazone inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA]; thymoquinone inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]PMID:18239056 PMID:18755807 PMID:20007851 PMID:24892905 PMID:27688165 PMID:27984176 PMID:28964808
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