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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308542
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt1
Name: sirtuin 1
Acc ID: CHEBI:134301
Term: salvianolic acid B
Definition: A member of the class of 1-benzofurans that is an antioxidant and free radical scavenging compound extracted from S. miltiorrhiza
Chemical ID: MESH:C076944
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt1multiple interactionsEXP 6480464CTDsalvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA]; salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]; SIRT1 protein affects the reaction [salvianolic acid B inhibits the reaction [Ethanol results in increased expression of MLXIPL protein]]PMID:24769256 PMID:27989594
Sirt1increases expressionISOSIRT1 (Homo sapiens)6480464CTDsalvianolic acid B results in increased expression of SIRT1 proteinPMID:24769256 PMID:27989594
Sirt1multiple interactionsISOSIRT1 (Homo sapiens)6480464CTDsalvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]; SIRT1 protein affects the reaction [salvianolic acid B results in decreased expression of CRP protein]PMID:27989594
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