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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308374
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sirt3
Name: sirtuin 3
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sirt3increases expressionEXP 6480464CTDMetformin results in increased expression of SIRT3 proteinPMID:30385301
Sirt3multiple interactionsEXP 6480464CTD[Arsenic Trioxide co-treated with Metformin] results in increased expression of SIRT3 protein; Metformin inhibits the reaction [Cisplatin results in decreased expression of SIRT3 mRNA]; Metformin inhibits the reaction [Cisplatin results in decreased expression of SIRT3 protein]PMID:30385301 PMID:36800006
Sirt3decreases expressionISOSirt3 (Mus musculus)6480464CTDMetformin results in decreased expression of SIRT3 mRNA; Metformin results in decreased expression of SIRT3 proteinPMID:23166782 PMID:24687991
Sirt3decreases response to substanceISOSirt3 (Mus musculus)6480464CTDSIRT3 protein results in decreased susceptibility to MetforminPMID:23166782
Sirt3multiple interactionsISOSIRT3 (Homo sapiens)6480464CTDMetformin results in increased expression of and results in increased activity of SIRT3 proteinPMID:33147367
Sirt3multiple interactionsISOSirt3 (Mus musculus)6480464CTDMetformin inhibits the reaction [GCG protein results in increased expression of SIRT3 mRNA]; SIRT3 promotes the reaction [Metformin inhibits the reaction [Cisplatin affects the localization of SLC2A4 protein]]; SIRT3 protein inhibits the reaction [Metformin results in decreased abundance of Adenosine Triphosphate]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX protein]]PMID:23166782 PMID:36800006
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