GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Sirt3 | decreases expression | ISO | Sirt3 (Mus musculus) | 6480464 | CTD | sodium arsenite results in decreased expression of SIRT3 protein | PMID:25979314 | Sirt3 | multiple interactions | ISO | Sirt3 (Mus musculus) | 6480464 | CTD | SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [FOXO3 protein binds to PPARGC1A promoter]]; SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [FOXO3 protein binds to SOD2 promoter]]; SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [INS1 protein results in increased uptake of Glucose]]; SIRT3 protein inhibits the reaction [sodium arsenite results in decreased expression of PPARGC1A protein]; SIRT3 protein inhibits the reaction [sodium arsenite results in decreased expression of SLC2A4 protein]; SIRT3 protein inhibits the reaction [sodium arsenite results in decreased expression of SOD2 protein]; SIRT3 protein inhibits the reaction [sodium arsenite results in increased phosphorylation of and affects the localization of and results in decreased activity of FOXO3 protein]; sodium arsenite inhibits the reaction [FOXO3 protein binds to SIRT3 protein] | PMID:25979314 | | ||||||||||||||||||||||
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