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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1308277 Species: Rattus norvegicus RGD Object: Gene Symbol: Akr1b10 Name: aldo-keto reductase family 1, member B10 (aldose reductase)

Acc ID: CHEBI:5001 Term: fenofibrate Definition: A chlorobenzophenone that has formula C20H21ClO4. CasRN: 49562-28-9 Chemical ID: MESH:D011345

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
multiple interactions	ISO	RGD:1317959	6480464	CTD	Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Daunorubicin] Fenofibrate inhibits the reaction [AKR1B10 protein results in increased reduction of Glyceraldehyde]	PMID:19028477
decreases activity	ISO	RGD:1317959	6480464	CTD	Fenofibrate results in decreased activity of AKR1B10 protein Fenofibrate results in decreased activity of AKR1B10 protein mutant form	PMID:18325492