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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1307646
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lpin1
Name: lipin 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lpin1increases expressionISOLPIN1 (Homo sapiens)6480464CTDDexamethasone results in increased expression of LPIN1 mRNAPMID:19853017
Lpin1increases expressionISOLpin1 (Mus musculus)6480464CTDDexamethasone results in increased expression of LPIN1 mRNAPMID:23493372 PMID:31053639
Lpin1multiple interactionsISOLpin1 (Mus musculus)6480464CTD[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LPIN1 mRNA; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LPIN1 protein; [Dexamethasone co-treated with butylparaben] results in increased expression of LPIN1 mRNA; ANGPTL4 gene mutant form inhibits the reaction [Dexamethasone results in decreased expression of LPIN1 mRNA]; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of LPIN1 protein]PMID:22956630 PMID:23428407 PMID:25559859 PMID:31053639
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